The GMR12E03 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).
Thermogenetic activation (using TrpA1UAS.(B).cKa at 28.5[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R26E07 and Hsap\RELAAD.R12E03 in adult females, but not males, significantly increases the amount of sleep, compared to controls; activation does not significantly affect locomotor activity of awake adult males, compared to controls.