Amino acid replacement: K593term.
The K593term mutation results in a truncated mutant protein that lacks the C-terminal portion of the ankyrin repeats and the RING fingers.
A19039749T
K593term | mib2-PA; K593term | mib2-PB; K593term | mib2-PC
K593term
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
flightless (with mib2S1259)
flightless (with mib2S1456)
mib2S0768 homozygous late stage 16 embryos display severe loss and detachment of somatic muscles, as compared to controls; mib2S0768 homozygous and mib2S0768/mib21 transheterozygous late stage 16 embryos present a bloated midgut phenotype, and an irregular arrangement of longitudinal visceral muscle fibers, as compared to controls.
mib2S1456/mib2S0768 and mib2S1259/mib2S0768 transheterozygotes present a fully (or nearly fully) penetrant flightless phenotype, as compared to controls.