UASt regulatory sequences drive expression of dco carrying the amino acid replacement K38R (producing a dominant negative protein) and in which the nuclear localization signal sequence has been mutated (from KRQK to NNQN). The protein is tagged at the C-terminal end with Tag:MYC.
Comments on Models/Modifiers Based on Experimental Evidence
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Disease-implicated variant(s)
Phenotypic Data
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Reference
The expression of dcoK38R.NLS-.UAS.Tag:MYC under the control of Scer\GAL4tim.PE does not have a significant effect on the circadian rhythmicity and period, as compared to controls.