FB2024_03 , released June 25, 2024
Allele: Dmel\vnUAS.cUa
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General Information
Symbol
Dmel\vnUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0320500
Feature type
allele
Associated gene
Dmel\vn
Associated Insertion(s)
Carried in Construct
P{UAS-vn.U}
Key Links
Transgenic product class
wild_type
(Scopelliti et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Scopelliti et al., 2014)
Mutagen
in vitro construct
(Scopelliti et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-vn.U}
Cytology
Description

UAS regulatory sequences drive expression of vn.

(Scopelliti et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
vn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of vnScer\UAS.cUa under the control of Scer\GAL4esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in midgut hyperplasia via an increase in both intestinal stem cell and enteroblast differentiation, along with a significant increase in the number of mitotic cells, as compared to controls.

      (Nie et al., 2015)

      Expression of vnScer\UAS.cUa under the control of Scer\GAL4how-24B results in intestinal stem cell hyperproliferation in the adult midgut.

      (Scopelliti et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of bunGD1392 or MadmGD7155 suppresses the increased number of mitotic cells seen in the midguts of flies expressing vnScer\UAS.cUa under the control of Scer\GAL4esg-NP5130.

      (Nie et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      vnScer\UAS.cUa
      vnUAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Unknown
      Secondary FlyBase IDs
        References (2)