FlyBase Allele Report: Dmel\Atg1[ninaE.Tag:MYC]

General Information

Symbol

Dmel\Atg1^{ninaE.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0319865

Feature type

allele

Associated gene

Dmel\Atg1

Associated Insertion(s)

Carried in Construct

P{ninaE-Atg1.MYC}

Also Known As

ninaE-atg1

Key Links

Transgenic product class

cDNA

(Wang et al., 2009)

wild_type

(Wang et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Wang et al., 2009)

wild_type

(Wang et al., 2009)

Mutagen

in vitro construct

(Wang et al., 2009)

Progenitor genotype

Carried in construct

P{ninaE-Atg1.MYC}

Cytology

Description

The ninaE promoter drives expression of the full-length Atg1 cDNA with a C-terminal Tag:MYC tag.

(Wang et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

ninaE

Encoded product / tool

Atg1

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^GMR.Q120

(Wang et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Atg1^{ninaE.Tag:MYC} is a suppressor of increased cell death phenotype of Rheb^UAS.cSa, Scer\GAL4^GMR.PU

(Wang et al., 2009)

Atg1^{ninaE.Tag:MYC} is a suppressor of increased cell death phenotype of Hsap\HTT^GMR.Q120

(Wang et al., 2009)

Atg1^{ninaE.Tag:MYC} is a suppressor of increased cell death phenotype of norpA^P24

(Wang et al., 2009)

NOT Suppressor of

Statement

Reference

Atg1^{ninaE.Tag:MYC} is a non-suppressor of increased cell death phenotype of ninaE^RH27

(Wang et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

Atg1^{ninaE.Tag:MYC} is a suppressor of rhabdomere phenotype of Hsap\HTT^GMR.Q120

(Wang et al., 2009)

Atg1^{ninaE.Tag:MYC} is a suppressor of photoreceptor neuron phenotype of Hsap\HTT^GMR.Q120

(Wang et al., 2009)

Atg1^{ninaE.Tag:MYC} is a suppressor of retina phenotype of norpA^P24

(Wang et al., 2009)

Atg1^{ninaE.Tag:MYC} is a suppressor of photoreceptor neuron phenotype of norpA^P24

(Wang et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Atg1^{ninaE.T:Hsap\MYC} with Scer\GAL4^GMR.PF Rheb^Scer\UAS.cSa suppresses the neuronal degeneration found upon expression of Rheb^Scer\UAS.cSa alone.

Direct induction of autophagy by expression of Atg1^{ninaE.T:Hsap\MYC} does not suppress cell death caused by the dominant ninaE^RH27 mutation.

norpA³⁶-mediated photoreceptor degeneration is significantly suppressed by expression of Atg1^{ninaE.T:Hsap\MYC}.

(Wang et al., 2009)

Xenogenetic Interactions

Statement

Reference

Direct induction of autophagy through expression of Atg1^{ninaE.T:Hsap\MYC} suppresses photoreceptor cell death in Hsap\HTT^GMR.Q120 flies.

(Wang et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Atg1^{ninaE.T:Hsap\MYC}

Atg1^{ninaE.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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