FlyBase Allele Report: Dmel\Dysb[NIG.6856R]

General Information

Symbol

Dmel\Dysb^NIG.6856R

Species

D. melanogaster

Name

FlyBase ID

FBal0314148

Feature type

allele

Associated gene

Dmel\Dysb

Associated Insertion(s)

Carried in Construct

P{NIG.6856R}

Also Known As

DdysbIR-1, DdysbIR-2

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21, Shao et al., 2011)

Progenitor genotype

Carried in construct

P{NIG.6856R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-6856R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | adult stage, with Scer\GAL4^Act5C.PI

(Shao et al., 2011)

abnormal courtship behavior | adult stage, with Scer\GAL4^repo

(Shao et al., 2011)

abnormal learning, with Scer\GAL4^GH146

(Mullin et al., 2015)

abnormal learning, with Scer\GAL4^NP1227

(Mullin et al., 2015)

abnormal neurophysiology | larval stage, with Scer\GAL4^elav-C155

(Shao et al., 2011)

lethal - all die before end of pupal stage, with Scer\GAL4^Act5C.PI

(Shao et al., 2011)

lethal - all die before end of pupal stage, with Scer\GAL4^repo

(Shao et al., 2011)

lethal - all die during embryonic stage, with Scer\GAL4^NP3233

(Shao et al., 2011)

some die during embryonic stage, with Scer\GAL4^NP3233

(Shao et al., 2011)

some die during pupal stage, with Scer\GAL4^Act5C.PI

(Shao et al., 2011)

some die during pupal stage, with Scer\GAL4^repo

(Shao et al., 2011)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

(Shao et al., 2011)

Detailed Description

Statement

Reference

Expression of Dysb^NIG.6856R under the control of either Scer\GAL4^NP1227 or Scer\GAL4^GH146 is sufficient to prevent the normal avoidance response seen following odor exposure. Restricting expression of Dysb^NIG.6856R to the adult stages using Scer\GAL80 produces the same result.

(Mullin et al., 2015)

Pan-neuronal expression of dysb^{NIG.IR-6856R-1} under the control of Scer\GAL4^elav-C155 causes a reduction in excitatory junctional amplitude in the larval neuromuscular junction compared to controls. No courtship behaviour defects are observed.

Expression of dysb^{NIG.IR-6856R-1} in muscles under the control of Scer\GAL4^C57 does not affect excitatory junctional current amplitude in the larval neuromuscular junction.

Ubiquitous expression of dysb^{NIG.IR-6856R-1} under the control of Scer\GAL4^Act5C.PI results in an increase in male-male courtship behaviour.

Expression of dysb^{NIG.IR-6856R-1} in glia under the control of Scer\GAL4^repo results in an increase in male-male courtship behaviour.

(Shao et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dysb^NIG.6856R

Dysb^{NIG.IR-6856R-1}

Dysb^{NIG.IR-6856R-2}

dysb^NIG.6856R

dysb^{NIG.IR-6856R-1}

dysb^{NIG.IR-6856R-2}

Name Synonyms

Secondary FlyBase IDs

FBal0275314
FBal0268973
FBal0268974

References (7)

Report Sections

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