UAS regulatory sequences drive expression of a mutant form of Hsap\TARDBP lacking the RNA recognition motif (residues 106-175).
Flies expressing Hsap\TARDBPΔRRM1.Scer\UAS in the eye under the control of Scer\GAL4GMR.PU do not show any signs of retinal degeneration.
Expression of Hsap\TARDBPΔRRM1.Scer\UAS in motor neurons under the control of Scer\GAL4D42 has no effect on lifespan compared to controls.