FlyBase Allele Report: Dmel\ITP[UAS.cHa]

General Information

Symbol

Dmel\ITP^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Hermann-Luibl

FlyBase ID

FBal0299569

Feature type

allele

Associated gene

Dmel\ITP

Associated Insertion(s)

Carried in Construct

P{UAS-ITP.H}

Also Known As

UAS-ITP

Key Links

Transgenic product class

wild_type

(Hermann-Luibl et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Hermann-Luibl et al., 2014)

Mutagen

in vitro construct

(Hermann-Luibl et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-ITP.H}

Cytology

Description

UASt regulatory sequences drive expression of the short ITP isoform.

(Hermann-Luibl et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ITP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of ITP^UAS.cHa under the control of Scer\GAL4^da.Switch.PT in adults fed with RU486 leads to an increased proportion of body fluids, water intake and propensity to start drinking; reduced survival under desiccation or under osmotic stress; and a decrease in the volume of consumed food, defecation rate and size of feces when compared to controls.

(Gáliková et al., 2018)

Flies expressing ITP^Scer\UAS.cHa under the control of either Scer\GAL4^tim.Scer\UAS or Scer\GAL4^tim.PE show barely any morning or evening activity bouts under 12 hour light: 12 hour dark conditions, and are almost completely arrhythmic under constant darkness conditions.

Expression of ITP^Scer\UAS.cHa under the control of any one of Scer\GAL4^P2.4.Pdf, Scer\GAL4^per.PK, Scer\GAL4^Clk.2341, Scer\GAL4^cry.PE, Scer\GAL4^elav.PLu or Scer\GAL4^386Y has no effect on rhythmicity or period length under constant darkness conditions.

(Hermann-Luibl et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Flies co-expressing ITP^GD3825 and Pdf^GD299 under the control of Scer\GAL4^tim.Scer\UAS show significantly altered sleep profiles compared to wild type. Total nighttime sleep is decreased, total daytime sleep is decreased, average number of sleep bouts per day is increased, and average sleep bout duration is decreased.

(Hermann-Luibl et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ITP^Scer\UAS.cHa

ITP^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Hermann-Luibl

Secondary FlyBase IDs

References (2)

Report Sections

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