FlyBase Allele Report: Dmel\trk[Δ]

General Information

Symbol

Dmel\trk^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0295444

Feature type

allele

Associated gene

Dmel\trk

Associated Insertion(s)

TI{TI}trk^Δ

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ends-out gene targeting

(Henstridge et al., 2014)

FLPase

(Henstridge et al., 2014)

I-SceI

(Henstridge et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{TI}trk^Δ

Cytology

Description

The trk coding sequence has been replaced by a w^+mW.hs marker.

(Henstridge et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

embryonic/larval segmentation phenotype | larval stage

(Johnson et al., 2015)

female sterile

(Henstridge et al., 2014)

viable

(Henstridge et al., 2014)

Phenotype Manifest In

cephalopharyngeal skeleton

(Johnson et al., 2015)

filzkorper

(Johnson et al., 2015, Henstridge et al., 2014)

Detailed Description

Statement

Reference

trk^Δ/trk^Δ results in a loss of terminal structures (reduction in posterior filzkorper, head skeleton defects) in larvae.

(Johnson et al., 2015)

Embryos laid by mutant females lack abdominal segments posterior to A7 and lack filzkorper.

(Henstridge et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

trk^Δ is rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^Y79A.UASp

(Henstridge et al., 2014)

Partially rescued by

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^UASp.Tag:MYC

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^{UASp.Tag:HA,Tag:MYC}

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^UASp.TagRFP

(Henstridge et al., 2014)

trk^Δ is partially rescued by trk^H71A.UASp/Scer\GAL4^{VP16.nanos.UTR}

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^L72A.UASp

(Henstridge et al., 2014)

trk^Δ is partially rescued by trk^G73A.UASp/Scer\GAL4^{VP16.nanos.UTR}

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^Y74A.UASp

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^S77A.UASp

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^S78A.UASp

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^E80A.UASp

(Henstridge et al., 2014)

trk^Δ is partially rescued by trk^L81A.UASp/Scer\GAL4^{VP16.nanos.UTR}

(Henstridge et al., 2014)

trk^Δ is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^P82A.UASp

(Henstridge et al., 2014)

Not rescued by

trk^Δ is not rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^UASp.EGFP

(Henstridge et al., 2014)

trk^Δ is not rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^{UASp.TagRFP,EGFP}

(Henstridge et al., 2014)

trk^Δ is not rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^K75A.UASp

(Henstridge et al., 2014)

trk^Δ is not rescued by Scer\GAL4^{VP16.nanos.UTR}/trk^R76A.UASp

(Henstridge et al., 2014)

Comments

The phenotype of embryos laid by trk^Δ females is not rescued by maternal expression of either trk^{Scer\UAS.P\T.T:Avic\GFP-EGFP}, trk^{Scer\UAS.P\T.T:Zzzz\eqFP578-TagRFP,T:Avic\GFP-EGFP}, trk^{K75A.Scer\UAS.P\T} or trk^{R76A.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

The phenotype of embryos laid by trk^Δ females is rescued by maternal expression of either trk^{Scer\UAS.P\T.T:Hsap\MYC} (31% of embryos are rescued), trk^{Scer\UAS.P\T.T:Ivir\HA1,T:Hsap\MYC} (16%), trk^{Scer\UAS.P\T.T:Zzzz\eqFP578-TagRFP} (63%), trk^{H71A.Scer\UAS.P\T} (40%), trk^{L72A.Scer\UAS.P\T} (46%), trk^{G73A.Scer\UAS.P\T} (74%), trk^{Y74A.Scer\UAS.P\T} (39%), trk^{S77A.Scer\UAS.P\T} (16%), trk^{S78A.Scer\UAS.P\T} (6%), trk^{Y79A.Scer\UAS.P\T} (95%), trk^{E80A.Scer\UAS.P\T} (15%), trk^{L81A.Scer\UAS.P\T} (12%) or trk^{P82A.Scer\UAS.P\T} (9%) under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Henstridge et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

92604

w^*; TI{TI}trk^Δ/CyO; P{UASp-tor.G}5.7

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

trk^Δ9.1

(Karunaraj et al., 2022)

trk^Δ

(Karunaraj et al., 2022, Johns et al., 2018, Johnson et al., 2015, Henstridge et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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