FB2024_03 , released June 25, 2024
Allele: Dmel\MarfUAS.Tag:HA
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General Information
Symbol
Dmel\MarfUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0294741
Feature type
allele
Associated gene
Dmel\Marf
Associated Insertion(s)
Carried in Construct
P{UAS-Marf.HA}
Key Links
Transgenic product class
wild_type
(Kim et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kim et al., 2013)
Mutagen
in vitro construct
(Kim et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Marf.HA}
Cytology
Description

UAS regulatory sequences drive expression of Marf that is tagged with Tag:HA.

(Kim et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Marf
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of MarfScer\UAS.T:Ivir\HA1 partially suppresses the increased cytoplasmic polyubiquitin aggregates (at 14 days post eclosion), but not the mitochondrial defects (abnormal morphology, decreased mitochondrial volume and decreased electron density of mitochondria, at 14 and 21 days post eclosion, respectively) exhibited by the dorsal longitudinal indirect flight muscles of LamCunspecified heterozygotes expressing LamCE174K.Scer\UAS under the control of Scer\GAL4Mhc.PW.

      The co-expression of LamCE174K.Scer\UAS and MarfScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mhc.PW results in dorsal longitudinal indirect flight muscles at 14 days post eclosion exhibiting mitochondria with decreased electron density in electron microscopy images, as compared to controls.

      (Li et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MarfScer\UAS.T:Ivir\HA1
      MarfUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)