FB2024_03 , released June 25, 2024
Allele: Dmel\5-HT2AGal4
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General Information
Symbol
Dmel\5-HT2AGal4
Species
D. melanogaster
Name
FlyBase ID
FBal0285936
Feature type
allele
Associated gene
Dmel\5-HT2A
Associated Insertion(s)
TI{GAL4}5-HT2AGal4
Carried in Construct
Also Known As
5-HT2A-Gal4
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Gasque et al., 2013)
Mutagen
gene targeting by homologous recombination
(Gasque et al., 2013)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}5-HT2AGal4
Cytology
Description

loxP and attP sites have also been introduced.

(Qian et al., 2017)

The first coding exon of 5-HT2A has been replaced by sequence encoding a GAL4 driver.

(Gasque et al., 2013)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike wild type, 5-HT2AGal4 larvae are resistant to 100μM metitepine, and show relatively higher feeding rates when fed with this drug.

      Unlike wild type, 5-HT2APL00052/5-HT2AGal4 larvae are resistant to 100μM metitepine, and show relatively higher feeding rates when fed with this drug.

      Unlike wild type, 5-HT2Ae01363/5-HT2AGal4 larvae are resistant to 100μM metitepine, and show relatively higher feeding rates when fed with this drug.

      5-HT2Ae01363/5-HT2AGal4 larvae eat less food than controls (in absence of metitepine).

      (Gasque et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Text says: "Generated by Juan Huang and Yi Rao, and will be reported elsewhere".

      (Gasque et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      5-HT2AGal4
      (Gasque et al., 2013)
      5HT2aGAL4
      (Qian et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)