lexAop regulatory sequences drive expression of a constitutively active form of Mmus\Prkaca.
Flies in which Ecol\lexALexPR.Scer\UAS expressed under the control of Scer\GAL4247 is used to drive expression of Mmus\PkacamC.Ecol\lexAop.cKa in the presence of RU486 show in a significant decrease in total sleep time, an increase in short duration sleep episodes (5-15 minutes) and a decrease in long-lasting sleep episodes (150-500 minutes) compared to controls, without significantly affecting sleep bout number.
Flies in which Ecol\lexAXVE.Scer\UAS expressed under the control of Scer\GAL4247 is used to drive expression of Mmus\PkacamC.Ecol\lexAop.cKa in the presence of β-estradiol show in a significant decrease in total sleep time, an increase in short duration sleep episodes (5-15 minutes) and a decrease in long-lasting sleep episodes (150-500 minutes) compared to controls, without significantly affecting sleep bout number.