FB2024_03 , released June 25, 2024
Allele: Dmel\Ten-mGS9267
Open Close
General Information
Symbol
Dmel\Ten-mGS9267
Species
D. melanogaster
Name
FlyBase ID
FBal0277971
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
P{GS}9267
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Expression of Ten-mGS9267 under the control of Scer\GAL4Mz19 results in ectopic connections between olfactory receptor neuron (ORN) axons expressing Or47b and DA1, VA1d and DC3 projection neuron (PN) dendrites expressing Scer\GAL4Mz19 (these axons and dendrites do not overlap in wild type). In addition, the position of the Scer\GAL4Mz19-expressing PN dendrites is shifted compared to wild type (although this alone is not enough to cause the ectopic ORN axon-PN dendrite connections).

    Clonal expression (using MARCM) of Ten-mGS9267 under the control of Scer\GAL4Mz19 in DA1 projection neurons, but not in VA1d/DC3 PNs, causes mismatching of the PN dendrites with Or47b-expressing ORNs and (to a lesser extent) with Or88a-expressing ORNs.

    Expression of Ten-mGS9267 under the control of Scer\GAL4AM29 in ORNs does not result in ectopic connections between the Ncra\QFMz19.PH-expressing PN dendrites and the ORN axons.

    Simultaneous expression of Ten-mGS9267 under the control of Scer\GAL4AM29 in ORNs and Ten-mNcra\QUAS.cHa under the control of Ncra\QFMz19.PH in PNs results in ectopic connections between the PN dendrites and the ORN axons.

    Expression of Ten-mGS9267 under the control of Scer\GAL4l(3)H94-H94 results in a shift of bouton distribution at the muscle 6/7 neuromuscular junction: 81% of boutons synapse onto muscle 6 and only 19% synapse onto muscle 7 in the mutant larvae (compared to 60% and 40% respectively in wild-type larvae). This effect is abolished if the larvae also carry either Scer\GAL80elav.PSb or Scer\GAL80Mhc.PW.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Ten-mGS9267
    Name Synonyms
    Secondary FlyBase IDs
      References (4)