FB2024_03 , released June 25, 2024
Allele: Hsap\CYP3A4UAS.cRa
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General Information
Symbol
Hsap\CYP3A4UAS.cRa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Rand
FlyBase ID
FBal0277786
Feature type
allele
Associated gene
Hsap\CYP3A4
Associated Insertion(s)
Carried in Construct
P{UAS-CYP3A4.R}
Key Links
Transgenic product class
cDNA
(Rand et al., 2012)
wild_type
(Rand et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Rand et al., 2012)
wild_type
(Rand et al., 2012)
Mutagen
in vitro construct
(Rand et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-CYP3A4.R}
Cytology
Description

UASt regulatory sequences drive expression of a Hsap\CYP3A4 cDNA.

(Rand et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\CYP3A4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing Hsap\CYP3A4Scer\UAS.cRa under the control of Scer\GAL4c754 show increased tolerance to methylmercury (shown as increased eclosion of adult flies on food containing 10μM and 15μM methylmercury compared to controls).

      Animals expressing Hsap\CYP3A4Scer\UAS.cRa under the control of Scer\GAL4elav-C155 show increased tolerance to methylmercury (shown as increased eclosion of adult flies on food containing 10μM methylmercury compared to controls).

      (Rand et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\CYP3A4Scer\UAS.cRa
      Hsap\CYP3A4UAS.cRa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Rand
      Secondary FlyBase IDs
        References (1)