FB2024_03 , released June 25, 2024
Allele: Dmel\MhcEMB-9c11d
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General Information
Symbol
Dmel\MhcEMB-9c11d
Species
D. melanogaster
Name
FlyBase ID
FBal0267791
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{Mhc.EMB-9c11d}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kronert et al., 2012)
Progenitor genotype
Mhc+memb
(Kronert et al., 2012)
Carried in construct
P{Mhc.EMB-9c11d}
Cytology
Description

The Mhc cDNA sequence present in Mhc+memb has been replaced with a cDNA encoding the naturally occurring EMB-9c11d Mhc isoform. The construct expresses alternative exons 3a, 7a, 9c, 11d and 15b and lacks exon 18.

(Kronert et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The indirect flight muscles of pupae carrying MhcEMB-9c11d in a Mhc10 background show apparent assembly defects such as abnormally shaped myofibrils with disrupted hexagonal filament packing, particularly at the periphery. The defects become progressively more severe during adulthood, such that by 1 week after eclosion the myofibrils are highly disorganised with thick and thin filaments scattered throughout the cytoplasm and disruption of the sarcomeres.

      (Kronert et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      MhcEMB-9c11d does not rescue flight or jump ability in a Mhc10 background.

      (Kronert et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MhcEMB-9c11d
      Name Synonyms
      Secondary FlyBase IDs
        References (1)