FB2024_03 , released June 25, 2024
Allele: Dmel\variMD109
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General Information
Symbol
Dmel\variMD109
Species
D. melanogaster
Name
FlyBase ID
FBal0266076
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Imprecise excision of the progenitor insertion, which results in a 1103bp deletion that removes exon 3a and part of the following intron. 464bp of the original insertion remain. This mutation affects specifically the short form of vari.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

1103 bp deletion resulting from the imprecise excision of P{XP}varid10880 464 bp of the original insertion remain at the site. Position of deletion on reference sequence inferred by FlyBase curator.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous and variMD109/vari03953b embryos die at the end of embryogenesis with convoluted tracheal tubes. Pleated septate junctions are missing between epidermal and between tracheal cells in stage 16 homozygous embryos, while adherens junctions are well developed.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)