FB2024_03 , released June 25, 2024
Allele: Dmel\par-1T408A.UAS.Tag:MYC
Open Close
General Information
Symbol
Dmel\par-1T408A.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0265784
Feature type
allele
Associated gene
Dmel\par-1
Associated Insertion(s)
Carried in Construct
P{UAS-par-1.T408A.MYC}
Also Known As
UAS-Par-1T408A
Key Links
Transgenic product class
missense_variant
(Wang et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang et al., 2007)
Mutagen
in vitro construct
(Wang et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-par-1.T408A.MYC}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of the par-1 α isoform in which the threonine at residue 408 has been replaced by an alanine. The construct is tagged with Tag:MYC.

(Wang et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
par-1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of par-1T408A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4BG380 in larval neuromuscular junctions does not lead to specific accumulation of a subset of synaptic cargo in axons, no difference in the number of active zones in synapses, no differences in the amplitude of mini excitatory junction potentials (mEJPs) or excitatory junction potentials (EJPs), no difference in the frequency of mEJPs, and no significant difference in quantal content, as compared to controls.

      (Barber et al., 2017)

      Expression of par-1T408A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 causes no growth or polarity defects in wing discs.

      (Skwarek et al., 2014)

      Expression of par-1T408A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ey-OK107 does not affect mushroom body morphology.

      (King et al., 2011)

      Expression of par-1T408A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF has no effect on eye morphology.

      (Wang et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      par-1T408A.Scer\UAS.T:Hsap\MYC
      par-1T408A.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (7)