FB2024_03 , released June 25, 2024
Allele: Hsap\PON1UAS.cSa
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General Information
Symbol
Hsap\PON1UAS.cSa
Species
H. sapiens
Name
FlyBase ID
FBal0260950
Feature type
allele
Associated gene
Hsap\PON1
Associated Insertion(s)
Carried in Construct
P{UAS-hPON1.S}
Key Links
Transgenic product class
cDNA
(Stoltz et al., 2008)
wild_type
(Stoltz et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Stoltz et al., 2008)
wild_type
(Stoltz et al., 2008)
Mutagen
in vitro construct
(Stoltz et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-hPON1.S}
Cytology
Description

Human Hsap\PON1R cDNA is cloned into pUAST under the control of UASt regulatory sequences.

(Stoltz et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\PON1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4αTub84B.PL have decreased superoxide levels in the midgut compared to controls. The gut microbiome is altered in these flies compared to wild type, with an increase in the gut load of Lactobacillus.

      (Pezzulo et al., 2012)

      Expression of Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4da.G32 protects flies from chlorpyrifos-induced toxicity. Expression of Hsap\PON1Scer\UAS.cSa does not protect flies from demeton-S-methyl exposure.

      Flies expressing Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4da.G32 are protected from Pseudomonas aeruginosa-induced lethality, independent of bacterial growth.

      Flies expressing Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4da.G32 are protected from Serratia marcescens-induced lethality but not Staphylococcus aureus infection.

      (Stoltz et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\PON1Scer\UAS.cSa
      Hsap\PON1UAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)