Flies expressing Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4αTub84B.PL have decreased superoxide levels in the midgut compared to controls. The gut microbiome is altered in these flies compared to wild type, with an increase in the gut load of Lactobacillus.
Expression of Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4da.G32 protects flies from chlorpyrifos-induced toxicity. Expression of Hsap\PON1Scer\UAS.cSa does not protect flies from demeton-S-methyl exposure.
Flies expressing Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4da.G32 are protected from Pseudomonas aeruginosa-induced lethality, independent of bacterial growth.
Flies expressing Hsap\PON1Scer\UAS.cSa under the control of Scer\GAL4da.G32 are protected from Serratia marcescens-induced lethality but not Staphylococcus aureus infection.