The embryonic isoform of Mhc with the adult-specific C-terminus (corresponding to exon 18) substituted for the embryonic isoform C-terminus (27 amino acids).
Approximately 50% of flies expressing Mhcemb.ex18 are incapable of flying up or horizontally.
Flies carrying Mhcemb.ex18 in a Mhc10 mutant background exhibit normal-looking myofibrils at the pupal stage in the central regions, but myofilaments at the periphery are less organized. In young adults, the myofibrils are disorganised with cracking and fraying throughout. In 1-week old flies the myofibrils appear fairly well organised. The appear compacted and smaller in diameter, but there is no cracking or fraying at the periphery.
Crossing of Mhcemb.ex18 with Mhc1 produces viable adults. These adults are flightless.
