Inhibition (using shits1.UAS.Tag:MYC at 31[o]C) of Scer\GAL4GMR72B08 cells in adults during retrieval, but not training or consolidation, significantly reduces 2 h aversive, or appetitive, olfactory memory, compared to controls; inhibition in combination with a paired odor results in a significant increase in short-term associative aversive olfactory memory in fed flies, and attractive memory in starved flies, compared to controls.
Inhibition (using shits1.UAS.Tag:MYC at 31[o]C) of a subset of Scer\GAL4GMR72B08 cells (expression restricted using Scer\GAL8012xCRE) in adults during retrieval, but not training or consolidation, significantly reduces 2 h aversive olfactory memory and inhibition during training, consolidation or retrieval significantly reduces 2 h appetitive olfactory memory, compared to controls; inhibition in combination with a paired odor results in a significant increase in short-term associative aversive olfactory memory in starved or fed flies, compared to controls.
Inhibition of the combined set of a subset of Scer\GAL4GMR72B08 cells (expression restricted using Scer\GAL8012xCRE) and neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R27G01 and Hsap\RELAAD.R15B01 in adults during training, consolidation or retrieval, significantly reduces 2 h aversive, but not appetitive, olfactory memory, compared to controls.
Thermogenetic activation (using TrpA1UAS.(B).cKa at 31[o]C) of a subset of Scer\GAL4GMR72B08 neurons (expression restricted using Scer\GAL8012xCRE) in adults during training, consolidation or retrieval significantly reduces 2 h aversive, but not appetitive, olfactory memory, compared to controls; activation in combination with a paired odor, results in a significant increase in short-term associative attractive olfactory memory in starved, but not fed flies, compared to controls.