FB2024_03 , released June 25, 2024
Allele: Scer\GAL4GMR72B08
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General Information
Symbol
Scer\GAL4GMR72B08
Species
S. cerevisiae
Name
FlyBase ID
FBal0254492
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
R72B08-Gal4, R72B08
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

A 3346 base pair fragment from the flanking non-coding or intronic region of DopR is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

Allele components
Component
Use(s)
Regulatory region(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference
 
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Inhibition (using shits1.UAS.Tag:MYC at 31[o]C) of Scer\GAL4GMR72B08 cells in adults during retrieval, but not training or consolidation, significantly reduces 2 h aversive, or appetitive, olfactory memory, compared to controls; inhibition in combination with a paired odor results in a significant increase in short-term associative aversive olfactory memory in fed flies, and attractive memory in starved flies, compared to controls.

Inhibition (using shits1.UAS.Tag:MYC at 31[o]C) of a subset of Scer\GAL4GMR72B08 cells (expression restricted using Scer\GAL8012xCRE) in adults during retrieval, but not training or consolidation, significantly reduces 2 h aversive olfactory memory and inhibition during training, consolidation or retrieval significantly reduces 2 h appetitive olfactory memory, compared to controls; inhibition in combination with a paired odor results in a significant increase in short-term associative aversive olfactory memory in starved or fed flies, compared to controls.

Inhibition of the combined set of a subset of Scer\GAL4GMR72B08 cells (expression restricted using Scer\GAL8012xCRE) and neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R27G01 and Hsap\RELAAD.R15B01 in adults during training, consolidation or retrieval, significantly reduces 2 h aversive, but not appetitive, olfactory memory, compared to controls.

Thermogenetic activation (using TrpA1UAS.(B).cKa at 31[o]C) of a subset of Scer\GAL4GMR72B08 neurons (expression restricted using Scer\GAL8012xCRE) in adults during training, consolidation or retrieval significantly reduces 2 h aversive, but not appetitive, olfactory memory, compared to controls; activation in combination with a paired odor, results in a significant increase in short-term associative attractive olfactory memory in starved, but not fed flies, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Scer\GAL4GMR72B08
Name Synonyms
Secondary FlyBase IDs
    References (8)