FB2024_03 , released June 25, 2024
Allele: Dmel\ninaCI1501E
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General Information
Symbol
Dmel\ninaCI1501E
Species
D. melanogaster
Name
FlyBase ID
FBal0244734
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Encodes the full-length ninaC p174 isoform with the amino acid replacement I1501E.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The electroretinogram response of flies carrying ninaCI1501E in a ninaC5 background is abnormal. The flies show a delay of approximately 1 second upon cessation of the intense light stimulus before the response begins to return to baseline. Once the response termination has started, the mutant flies return more slowly than normal to the dark state. Often, a small repolarisation occurs coincident with cessation of the light stimulation, followed by the delay before full repolarisation. The mutant flies do not show a prolonged depolarisation phenotype.

Intracellular electrophysiological responses of photoreceptor cells in flies carrying ninaCI1501E in a ninaC5 background are abnormal. There is a significant delay in termination of the photoresponse. There is no significant defect in adaptation.

Flies carrying ninaCI1501E in a ninaC5 background do not show retinal degeneration.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)