FB2024_03 , released June 25, 2024
Allele: Dmel\sroP54
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General Information
Symbol
Dmel\sroP54
Species
D. melanogaster
Name
FlyBase ID
FBal0244250
Feature type
allele
Associated gene
Dmel\sro
Associated Insertion(s)
P{}sroP54
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Giesen et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{}sroP54
Cytology
Description

The P{}sroP54 insertion (which is inserted in the region upstream of kay) causes loss of function of both the kay and sro genes; there is a large reduction in the CG12068 transcript level (the annotation corresponding to sro) in homozygous embryos and the P{}sroP54 chromosome fails to complement mutations in both kay (kay1) and sro (sroO4-105 and sro1).

(Niwa et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show a severe "shroud" cuticle phenotype.

      (Giesen et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sro1

      (Niwa et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The "shroud" mutant phenotype is reverted by precise excision of the insertion.

      (Giesen et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sroP54
      (Niwa et al., 2010, Giesen et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)