Embryos derived from homozygous pog1 germ line clones show severe defects in germ band extension, but no defects in ventral furrow formation.
The Mon1156 mutation was identified as an amber mutation within the Mon1 coding sequence on the chromosome carrying the pog1 mutant allele. Lethality of the chromosome in transheterozygous combination with the Mon1Δ181 mutant can be rescued by overexpression of Mon1, confirming that Mon1 gene function is disrupted by the Mon1156 mutation. However, the homozygous lethality of this chromosome cannot be rescued by overexpression of Mon1, indicating that the chromosome also carries a second site mutation that contributes to the lethality of the chromosome. FlyBase curator comment: it is not yet clear whether the 'poor gastrulation' phenotype for which the unmapped pog1 mutation was named is due to disrupted function of the Mon1 gene (caused by the Mon1156 mutation) and/or due to the second site mutation on the chromosome, thus the pog1 allele and parent pog gene have been kept as separate entities in FlyBase from Mon1156 and Mon1 until more information becomes available [date: 200812].
The pog1 mutation was initially incorrectly ascribed to 'CG31660'/'smog' (in FBrf0208913) - FBrf0231092 shows that pog1 complements the smognull deletion of CG31660.