Flies expressing Dys^{dsRNA.RB.Scer\UAS} under the control of Scer\GAL4^tub or Scer\GAL4^how-24B show comparable climbing ability at the beginning of adult life to control flies. However, the ability of these animals to climb declines significantly faster over time compared to controls. Animals expressing Dys^{dsRNA.RB.Scer\UAS} under the control of Scer\GAL4^tub exhibit mostly normal muscle architecture at 3 days after eclosion. By 12 days, age-dependent muscle degeneration is observed including loss of muscle fibre organisation, vacuolisation and the absence of some muscles.

Expression of Dys^{dsRNA.RB.Scer\UAS} in the eye disc (under the control of Scer\GAL4^GMR.PU), or in all glial cells (under the control of Scer\GAL4^repo.PU), both result in photoreceptor axon targeting defects. Axons stop irregularly, making gaps in the normal termination zone of the lamina plexus, deviating from the path and bundling aberrantly. Expression of Dys^{dsRNA.RB.Scer\UAS} in the mesodermal tissue (under the control of Scer\GAL4^how-24B) does not effect the axon termination process.