FlyBase Allele Report: Dmel\upd3[HM05061]

General Information

Symbol

Dmel\upd3^HM05061

Species

D. melanogaster

Name

FlyBase ID

FBal0239393

Feature type

allele

Associated gene

Dmel\upd3

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05061}

Also Known As

upd3-i, UAS-upd3 RNAi#2, UAS-upd3 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05061}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05061

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of upd3^HM05061 under the control of Scer\GAL4^elav.PU no effect on attraction to food cues or food intake in adult flies.

(Beshel et al., 2017)

Expression of upd3^HM05061 under the control of Scer\GAL4^ppl.PP does not result in a reduction in body size.

Expression of upd3^HM05061 under the control of Scer\GAL4^Cg.PA has no effect on triacylglycerol levels in adults.

(Rajan and Perrimon, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

upd1^JF03149/upd3^HM05061, Scer\GAL4^ap-md544 is a suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

Scer\GAL4^NP0001/upd3^HM05061 is a suppressor of increased occurrence of cell division phenotype of Scer\GAL4^NP0001, ebd1^JF02926

(Tian et al., 2017)

Scer\GAL4^NP0001/upd3^HM05061 is a suppressor of increased cell number phenotype of Scer\GAL4^NP0001, ebd1^JF02926

(Tian et al., 2017)

upd3^HM05061, Scer\GAL4^ptc-559.1 is a suppressor | partially of hyperplasia phenotype of N^UAS.icd, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

NOT Suppressor of

Statement

Reference

upd3^HM05061, Scer\GAL4^ap-md544 is a non-suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

Other

Statement

Reference

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^NP0001/upd3^HM05061 is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^NP0001, ebd1^JF02926

(Tian et al., 2017)

Scer\GAL4^NP0001/upd3^HM05061 is a suppressor of intestinal stem cell | increased number | adult stage phenotype of Scer\GAL4^NP0001, ebd1^JF02926

(Tian et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The increased number of intestinal stem cells along with the number of mitotic cells in the midgut of adult flies expressing ebd1^JF02926 under the control of Scer\GAL4^{Myo31DF-NP0001} (combined with Gal80[ts] to limit the time of expression to adulthood) can be suppressed by co-expression of upd3^HM05061.

(Tian et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28575

y¹ v¹; P{TRiP.HM05061}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Upd3^RNAi

(Ma et al., 2019)

upd3^HM05061

upd3^RNAi1

(Chen et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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