Expression of M6^KK109436 under the control of Scer\GAL4^Act5C.PU results in pupal lethality.

Expression of M6^KK109436 under the control of Scer\GAL4^Bx-MS1096 results in diminished wing size, abnormal curling, and loss of one or both cross veins.

Expression of M6^KK109436 under the control of Scer\GAL4^repo.PU, Scer\GAL4^GMR.PU or Scer\GAL4^elav.PU does not lead to lethality or morphological changes.

Expression of M6^KK109436 under the control of Scer\GAL4^Mef2.247 does not lead to significant learning or memory defects.

Expression of M6^KK109436 under the control of Scer\GAL4^dm-PG45 in adult females (using the temperature sensitive Scer\GAL80^ts.αTub84B allele to restrict expression) results in a reduction in female fertility compared to controls after shifting to 29[o]C. There is also an increase in the percentage of permeable eggs laid by these females compared to those laid at 18[o]C. The permeable egg phenotype is reversible upon shifting back to 18[o]C.

Females expressing M6^NIG.7540R under the control of Scer\GAL4^dm-PG45 at 32[o]C for 72 hours (to inactivate the temperature-sensitive Scer\GAL80^ts.αTub84B repressor) show a clear disruption in oogenesis, with no egg chambers between stages 9 to 13 being identifiable. In addition, both polar and border cells do not migrate in stage 9 egg chambers and remain at the anterior region.