FlyBase Allele Report: Dmel\anne[KK107621]

General Information

Symbol

Dmel\anne^KK107621

Species

D. melanogaster

Name

FlyBase ID

FBal0235049

Feature type

allele

Associated gene

Dmel\anne

Associated Insertion(s)

Carried in Construct

P{KK107621}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107621}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107621

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Kufor-Rakeb syndrome

CEA

(Dhanushkodi et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Kufor-Rakeb syndrome

is exacerbated by Hsap\SNCA^A30P.UAS

(Dhanushkodi et al., 2023)

is exacerbated by Hsap\SNCA^A53T.UAS

(Dhanushkodi et al., 2023)

is exacerbated by Hsap\SNCA^UAS.cFa

(Dhanushkodi et al., 2023)

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(Dhanushkodi et al., 2023)

modeled by Hsap\SNCA^A53T.UAS

(Dhanushkodi et al., 2023)

modeled by Hsap\SNCA^A30P.UAS

(Dhanushkodi et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sleep | adult stage, with Scer\GAL4^Ddc.PL

(Dhanushkodi et al., 2023)

increased rate of adult locomotory behavior, with Scer\GAL4^Ddc.PL

(Dhanushkodi et al., 2023)

lethal - all die before end of pupal stage, with Scer\GAL4^Mef2.PR

(Ham et al., 2021)

visible | adult stage, with Scer\GAL4^GMR.long

(Dhanushkodi et al., 2023)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.long

(Dhanushkodi et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

anne^KK107621, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor rhythm | adult stage phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL

(Dhanushkodi et al., 2023)

anne^KK107621, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor rhythm | adult stage phenotype of Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL

(Dhanushkodi et al., 2023)

Other

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL, anne^KK107621 has decreased cell number | adult stage phenotype

(Dhanushkodi et al., 2023)

Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL, anne^KK107621 has decreased cell number | adult stage phenotype

(Dhanushkodi et al., 2023)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL, anne^KK107621 has decreased cell number | adult stage phenotype

(Dhanushkodi et al., 2023)

Phenotype Manifest In

Other

Statement

Reference

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL, anne^KK107621 has adult dopaminergic neuron | decreased number phenotype

(Dhanushkodi et al., 2023)

Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL, anne^KK107621 has adult dopaminergic neuron | decreased number phenotype

(Dhanushkodi et al., 2023)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL, anne^KK107621 has adult dopaminergic neuron | decreased number phenotype

(Dhanushkodi et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105477

P{KK107621}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG32000^KK107621

anne^KK107621

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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