FlyBase Allele Report: Dmel\Mps1[C3]

General Information

Symbol

Dmel\Mps1^C3

Species

D. melanogaster

Name

FlyBase ID

FBal0221033

Feature type

allele

Associated gene

Dmel\Mps1

Associated Insertion(s)

Carried in Construct

Also Known As

ald^C3

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Wu et al., 2008)

Mutagen

Progenitor genotype

Cytology

Description

A 9-codon deletion (Δ369-377) near the kinase active site.

(Gilliland et al., 2007)

ald^C3 has a 27bp deletion that deletes amino acids 369-377 from the kinase domain of the protein.

(Page et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:17,672,757..17,672,783 [+]

Comment:

A 9-codon deletion (Δ369-377) near the kinase active site.

Comment:

A 27 bp deletion which removes amino acids 369-377.

(Gilliland et al., 2007, Page et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Gilliland et al., 2007)

abnormal meiotic cell cycle (with Mps1^Exc23)

(Gilliland et al., 2007)

lethal - all die during embryonic stage

(Page et al., 2007)

partially lethal - majority die

(Gilliland et al., 2007)

some die during embryonic stage

(Page et al., 2007)

Phenotype Manifest In

chromosome & oocyte (with Mps1^ald-1)

(Wu et al., 2008)

oocyte

(Gilliland et al., 2007)

oocyte (with Mps1^Exc23)

(Gilliland et al., 2007)

spindle microtubule & oocyte (with Mps1^ald-1)

(Wu et al., 2008)

spindle pole & oocyte (with Mps1^ald-1)

(Wu et al., 2008)

Detailed Description

Statement

Reference

ald¹/ald^C3 females show 8.2% nondisjunction of the X chromosome.

33% of oocytes show disorganisation of the chromosomes in ald¹/ald^C3 females. The oocytes also show spindle defects; 10% have frayed spindles, 14% of spindles are monopolar and 5% lack tapering at the pole.

(Wu et al., 2008)

Cytological studies of ald^C3/ald^Exc23 mutant oocytes reveals a high frequency of chromosomes that appear to have procociously entered anaphase I, and in which achiasmate homologs are often seen as still physically associated and thus perhaps 'trapped' on one side of the spindle. Visualisation of meiosis in ald^C3/ald^Exc23 oocytes by live video microscopy reveals that shortly after spindle formation, the DNA fails to remain as a single mass at the metaphase plate, and soon enters an anaphase-like configuration where first the chromosomes and then the spindle appears to divide into two masses. This entry into anaphase takes less time than achiasmate homologs often require to achieve proper orientation, and is never observed during wild-type prometaphase.

(Gilliland et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mps1^C3

ald^C3

(Wu et al., 2008, Gilliland et al., 2007, Page et al., 2007)

ald^c3

(Das et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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