FB2024_03 , released June 25, 2024
Allele: Dmel\Dop2RJF02025
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General Information
Symbol
Dmel\Dop2RJF02025
Species
D. melanogaster
Name
FlyBase ID
FBal0220007
Feature type
allele
Associated gene
Dmel\Dop2R
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02025}
Also Known As
Dop2R-RNAi, Dop2R RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF02025}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02025
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Scer\GAL4NP2631 under the control of Scer\GAL4GH146 significantly reduces short term aversive olfactory memory, compared to controls.

      (Zhou et al., 2019)

      As in wild-type, female flies expressing D2RJF02025 under the control of Scer\GAL4elav.Switch.PO (induced by RU486) show an increased sugar-sensitive proboscis extension reflex (PER) in response to L-Dopa feeding.

      (Inagaki et al., 2012)

      Down-regulation of D2R through expression of D2RJF02025 under the control of Scer\GAL4elav-C155 reduces the larval feeding rate.

      Down-regulation of D2R during the 2nd instar larval stage, through expression of D2RJF02025 under the control of Scer\GAL4elav.Switch.PO (and RU486) does not affect larval feeding.

      Down-regulation of D2R in DA neurons through expression of D2RJF02025 under the control of Scer\GAL4l.Trh.PK reduces the larval feeding rate. Reduced DA signalling results in increased branching and varicosity area, due to ncreased numbers of larger 5-HT-containing vesicles. Down-regulation of D2R in serotonergic neurons, under the control of Scer\GAL4ple.PF fails to affect larval feeding.

      (Neckameyer and Bhatt, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      D2RJF02025
      Dop2RJF02025
      Name Synonyms
      Secondary FlyBase IDs
        References (12)