FB2024_03 , released June 25, 2024
Allele: Dmel\5-HT1AJF01852
Open Close
General Information
Symbol
Dmel\5-HT1AJF01852
Species
D. melanogaster
Name
FlyBase ID
FBal0219861
Feature type
allele
Associated gene
Dmel\5-HT1A
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01852}
Also Known As
JF01852, 5-HT1ARNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF01852}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01852
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The only 'high intensity fighting' (HIF) behaviour shown in male-male aggression assays by flies expressing 5-HT1AJF01852 via Scer\GAL4Ilp2.PR, whereas controls also shown wing threats and lunging. Unlike controls, feeding the mutant flies the 5-HT agonist 8-OH-DPAT does not change their HIF aggression pattern.

      Male flies expressing 5-HT1AJF01852 via Scer\GAL4Ilp2.PR that are fed the 5-HT agonist 8-OH-DPAT show a similar decrease in courtship singing behaviour as controls.

      Male flies expressing 5-HT1AJF01852 via Scer\GAL4Ilp2.PR show (i) a substantial decrease in abdomen curling latency; (ii) a significantly higher courtship index; and (iii) an increase in the tendency to attempt copulation in male-female courtship assays.

      Male flies expressing 5-HT1AJF01852 via Scer\GAL4Ilp2.PR show similar locomotor activity to controls.

      Male flies expressing 5-HT1AJF01852 via Scer\GAL4Ilp2.PR show similar sleep/wake patterns to controls.

      Male flies expressing 5-HT1AJF01852 via Scer\GAL4Ilp2.PR show normal circadian activity rhythm.

      (Williams et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      5-HT1AJF01852
      Name Synonyms
      Secondary FlyBase IDs
        References (7)