Expression of Shark^JF01794 in muscle under the control of Scer\GAL4^Mef2.PU results in significant hyperglycaemia.

Under normal nutritional conditions egg chambers from flies expressing shark^JF01794 under the control of Scer\GAL4^GR1 develop normally through mid-oogenesis. However, when degenerating egg chambers are induced by starvation the mutant flies show significant defects in the normal engulfment of dying germline cells. Unlike in wild type, the follicle cells fail to enlarge as nurse cell chromatin condenses and minimal uptake of nuclear fragments is seen. As egg chamber death progresses, the follicle cells die without clearing most of the nurse cell debris.