FlyBase Allele Report: Dmel\rpr[GD4698]

General Information

Symbol

Dmel\rpr^GD4698

Species

D. melanogaster

Name

FlyBase ID

FBal0210490

Feature type

allele

Associated gene

Dmel\rpr

Associated Insertion(s)

Carried in Construct

P{GD4698}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4698}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4698

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^en.PU-mediated expression of rpr^GD4698 does not result in wing blisters.

(Fereres et al., 2013)

Adults expressing rpr^GD4698 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4698

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^sd.PU/rpr^GD4698 is a suppressor of increased cell death phenotype of Scer\GAL4^sd.PU, SkpA^HM05185

(Fereres et al., 2013)

rpr^GD4698/Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of hid^GMR.PG

(Sandu et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^sd.PU/rpr^GD4698 is a suppressor of wing disc phenotype of Scer\GAL4^sd.PU, SkpA^HM05185

(Fereres et al., 2013)

rpr^GD4698, Scer\GAL4^en.PU is a suppressor of wing phenotype of RYBP^RNAi.UAS.cGa, Scer\GAL4^en.PU

(Fereres et al., 2013)

rpr^GD4698/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of hid^GMR.PG

(Sandu et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of rpr^GD4698 strongly reduces the cell death induced in wing discs by Scer\GAL4^sd.PU-mediated expression of SkpA^HM05185.

Co-expression of rpr^GD4698 completely suppresses the appearance of wing blisters in RYBP^{dsRNA.Scer\UAS.cGa} Scer\GAL4^en.PU flies.

(Fereres et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

rpr^GD4698/Scer\GAL4^GMR.PF rescues rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

Comments

Co-expression of rpr^GD4698 rescues eye morphology defects caused by expression of rpr^{UTR.Scer\UAS.T:Ivir\HA1} (where both transgenes are under the control of Scer\GAL4^GMR.PF).

(Sandu et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v12045

w¹¹¹⁸; P{GD4698}v12045

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts