FlyBase Allele Report: Dmel\Gαo[GDP.UAS]

General Information

Symbol

Dmel\Gαo^GDP.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0183488

Feature type

allele

Associated gene

Dmel\Gαo

Associated Insertion(s)

Carried in Construct

P{UAS(-FRT)Gαo.GDP}

Also Known As

UAS-Go^GDP, UAS-Go-GDP

Key Links

Transgenic product class

missense_variant

(Katanaev et al., 2005)

Mutagen

FLPase

Nature of the Allele

Transgenic product class

missense_variant

(Katanaev et al., 2005)

Mutagen

FLPase

(Katanaev et al., 2005)

Progenitor genotype

Gαo^FRT.GDP.UAS

(Katanaev et al., 2005)

Carried in construct

P{UAS(-FRT)Gαo.GDP}

Cytology

Description

Amino acid replacement: G203T.

(Dahdal et al., 2010)

The FRT cassette has been excised, juxtaposing the UAS regulatory sequences and mutant form of the Gαo class II isoform. Encodes a form of Gαo which is maintained in the GDP bound state.

(Katanaev et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Gαo

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm, with Scer\GAL4^P0.5.Pdf

(Dahdal et al., 2010)

abnormal neuroanatomy, with Scer\GAL4^repo

(Schwabe et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of G-oα47A^GDP.Scer\UAS in LN[[v]] neurons under the control of Scer\GAL4^P0.5.Pdf results in a ~1 hr longer period than control flies.

(Dahdal et al., 2010)

Expression of G-oα47A^GDP.Scer\UAS in glia of embryos, driven by Scer\GAL4^repo, causes defects in the formation of the blood-brain barrier, as assessed by the penetrance of a fluorescent dye into the nerve cord.

(Schwabe et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

G-oα47A^GDP.Scer\UAS

Gαo^GDP.Scer\UAS

Gαo^GDP.UAS

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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