FB2024_03 , released June 25, 2024
Allele: Dmel\5-HT7UAS.cKa
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General Information
Symbol
Dmel\5-HT7UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Kerr
FlyBase ID
FBal0176431
Feature type
allele
Associated gene
Dmel\5-HT7
Associated Insertion(s)
Carried in Construct
P{UAS-5-HT7.K}
Key Links
Transgenic product class
wild_type
(Kerr et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kerr et al., 2004)
Mutagen
in vitro construct
(Kerr et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-5-HT7.K}
Cytology
Description

Expression of the 1.7kb ORF of 5-HT7 is under the control of UASt sequences.

(Kerr et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
5-HT7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectopic expression of 5-HT7Scer\UAS.cKa in adult male flies (under the control of Scer\GAL4Ilp2.PW results in a significantly reduced lifespan at starvation.

      (Luo et al., 2012)

      5HT stimulates cAMP production in a dose-dependent manner in Malpighian tubules isolated from 5-HT7Scer\UAS.cKa; Scer\GAL4c42 or 5-HT7Scer\UAS.cKa; Scer\GAL4tsh-c724 flies. This is acompanied by an increase in fluid secretion from the tubules. cGMP levels are unaffected. These increases in fluid secretion and cAMP levels are both inhibited by butaclamol.

      (Kerr et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      5-HT7Scer\UAS.cKa
      5-HT7UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Kerr
      (Kerr et al., 2004)
      Secondary FlyBase IDs
        References (2)