FB2024_03 , released June 25, 2024
Allele: Dmel\robo2Δcyto.UAS.Tag:MYC
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General Information
Symbol
Dmel\robo2Δcyto.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0175610
Feature type
allele
Associated gene
Dmel\robo2
Associated Insertion(s)
Carried in Construct
P{UAS-robo2.Δcyto.myc}
Key Links
Transgenic product class
inframe_deletion
(Kraut and Zinn, 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kraut and Zinn, 2004)
Mutagen
in vitro construct
(Kraut and Zinn, 2004)
Progenitor genotype
Carried in construct
P{UAS-robo2.Δcyto.myc}
Cytology
Description

UAS regulatory sequences drive expression of robo2 which lacks the cytoplasmic domain and is tagged with Tag:MYC.

(Kraut and Zinn, 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
robo2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of robo2Δcyto.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Pdf.PU results in adult sLNv neurons exhibiting significantly longer axon projections and overshooting their targets, as compared to controls; this defect occurs in the late pupa.

      (Oliva et al., 2016)

      Expression of robo2Δcyto.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu in embryos results in ectopic crossing of the midline by Fas2-positive axons in all segments.

      (Evans et al., 2015)

      At 29oC, 5.4% of abdominal segments have partial or complete transformation of lch5 chordotonal organ morphology towards that of the thoracic dch3 chordotonal organs, in larvae expressing leaΔcyto.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL448Y. In addition, 9% of thoracic segments show transformation of the dch3 chordotonal organs to a morphology resembling that of abdominal lch5 chordotonal organs in these animals.

      (Kraut and Zinn, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      J. Simpson

      (Kraut and Zinn, 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      leaΔcyto.Scer\UAS.T:Hsap\MYC
      robo2Δcyto.Scer\UAS.T:Hsap\MYC
      robo2Δcyto.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)