FB2024_03 , released June 25, 2024
Allele: Dmel\eya54C2
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General Information
Symbol
Dmel\eya54C2
Species
D. melanogaster
Name
FlyBase ID
FBal0144311
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bai and Montell, 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q269term.

(Tian et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,529,626..6,529,626 [-]
Nucleotide change:

C6529626G

Amino acid change:

Q275E | eya-PA; Q269E | eya-PB; Q185E | eya-PC

Reported amino acid change:

Q269term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Tian et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eya2/eya4 and eya2/eya3 adults exhibit significantly higher number of ommatidia in the eye than eya2/eya54C2 adults.

      (Tian et al., 2019)

      Mosaic stage 10 egg chambers containing eya54C2 follicle cell clones contain either multiple clusters of migrating border cells or a single abnormally large border cell cluster. The extra border cell clusters that form contain extra polar cells. Ectopic polar cells are seen in early stage egg chambers and are found in many positions throughout the follicle epithelium in egg chambers containing mutant clones. eya54C2 clones in the head are show loss of eye tissue which is replaced by head cuticle containing orbital bristles. Mutant clones do not result in abnormalities in the legs or wings.

      (Bai and Montell, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      eya2

      (Tian et al., 2019)
      Fails to complement

      eya4

      (Tian et al., 2019)

      eyaunspecified

      (Bai and Montell, 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      eya54C2
      (Tian et al., 2019, Chang et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)