FB2024_03 , released June 25, 2024
Allele: Dmel\btvk07109b
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General Information
Symbol
Dmel\btvk07109b
Species
D. melanogaster
Name
FlyBase ID
FBal0141229
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
btv2
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Single nucleotide deletion in exon 22 of btv. This results in a frameshift and a premature stop codon.

    btvk07109b is likely a "hit and run" lesion. It is not associated with the 'k07109b' insertion of the P{lacW} element, which is actually present in the Fas3 gene, nearby.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Comment:

    A single base deletion was reported at 2L:17966613 within the btv coding region that leads to a frameshift and early translation termination.

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In

    abdominal lateral pentascolopidial chordotonal organ lch5 & scolopidium

    Detailed Description
    Statement
    Reference

    The arrangement and numbers of scolopidia in the abdominal lateral pentascolopidial chordotonal organs of these larvae are normal. However, these scolopidia have significant morphological defects, both in their outer dendritic segments and ciliary dilation. btvk07109b homozygous larvae have reduced touch sensitivity compared to wild-type. Locomotion in these larvae is aberrant: compared to controls they larvae are slower and pause, turn and retreat more often. These defects in locomotion arise at least partially from defective peristaltic motion: maximum larval length, stride period and % positive and negative flow are all defective. Despite their locomoter defects, these larvae exhibit normal phototaxic behaviour.

    External Data
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    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (5)