FB2024_04 , released June 25, 2024
Allele: Dmel\eUAS.cWa
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General Information
Symbol
Dmel\eUAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Wittkopp
FlyBase ID
FBal0138233
Feature type
allele
Associated gene
Dmel\e
Associated Insertion(s)
Carried in Construct
P{UAS-e.W}
Also Known As
UAS-ebony
Key Links
Transgenic product class
cDNA
(Wittkopp et al., 2002)
wild_type
(Wittkopp et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wittkopp et al., 2002)
wild_type
(Wittkopp et al., 2002)
Mutagen
in vitro construct
(Wittkopp et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-e.W}
Cytology
Description

A full length 1.9kb e cDNA is driven by UASt sequences.

(Wittkopp et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
e
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of eScer\UAS.cWa under the control of Scer\GAL4pnr-MD237 causes increased yellow pigmentation in the abdominal cuticle.

      (Wittkopp et al., 2009)

      eScer\UAS.cWa when driven by Scer\GAL4pnr-MD237, suppresses black pigment formation in all epidermal cells. In the thorax the cuticle lightens slightly relative to wild-type. In the abdomen a striking inhibition of melanin formation is seen, which is replaced with a tan pigment.

      (Wittkopp et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of eScer\UAS.cWa abolishes the thorax pigmentation defects seen in Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 flies.

      (Sekine et al., 2011)

      Simultaneous co-expression of eScer\UAS.cWa and tScer\UAS.cTa under the control of Scer\GAL4pnr-MD237 results in a pigmentation phenotype in the abdominal cuticle that is intermediate to that caused by expression of either eScer\UAS.cWa or tScer\UAS.cTa alone.

      (Wittkopp et al., 2009)

      When yScer\UAS.cCa and eScer\UAS.cWa are driven together by Scer\GAL4pnr-MD237 induces the formation of more black melanin than eScer\UAS.cWa alone, though the wild-type level of pigmentation is not restored.

      (Wittkopp et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      eScer\UAS.cWa
      eUAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wittkopp
      (Wittkopp et al., 2002)
      Secondary FlyBase IDs
        References (3)