FB2024_03 , released June 25, 2024
Allele: Dmel\sav1
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General Information
Symbol
Dmel\sav1
Species
D. melanogaster
Name
FlyBase ID
FBal0138137
Feature type
allele
Associated gene
Dmel\sav
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q289term.

    (Tapon et al., 2002)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:23,059,931..23,059,931 [-]
    Nucleotide change:

    C23059931T

    Amino acid change:

    Q289term | sav-PA; Q284term | sav-PB

    Reported amino acid change:

    Q289term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Tapon et al., 2002)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        sav1/sav3 animals and sav1/Df(3R)EB6 animals have a hatching rate of 85.5% and 83.3% respectively. 90-95% of animals of these genotypes fail to grow and die as first instar larvae. Mosaic flies with eyes containing clones homozygous for sav1 (clones generated using the "eyFLP" system) have eyes with an increased representation of mutant tissue over wild-type tissue. In mutant clones in the adult retina, almost all the ommatidia contain the normal complement of eight photoreceptor cells. However there is increased spacing between adjacent ommatidia - there are many additional interommatidial cells.

        (Tapon et al., 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        sav1 allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals).

        (Tyler et al., 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments

        sav1 fails to complement the lethality of Df(3R)hh.

        (Tapon et al., 2002)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        sav1
        (Tyler et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)