FB2024_03 , released June 25, 2024
Allele: Dmel\Clkper.Tag:HA
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General Information
Symbol
Dmel\Clkper.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0137563
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Approximately 4kb of per 5' sequences (containing circadian regulatory sequences) drives expression of the Clk open reading frame tagged with Tag:HA.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying Clkper.T:Ivir\HA1 have locomotor activity rhythms with normal period lengths of about 24 hours at 25oC or 29oC under constant darkness conditions. Most of the flies show robust rhythms. There are no differences in the waveform of the activity rhythm in Clkper.T:Ivir\HA1 and control flies under constant darkness conditions; the duration of morning activity, the portion of activity occurring during the subjective day and timing of the upswing, peak and downswing in either morning or evening bouts of activity are all normal in Clkper.T:Ivir\HA1 flies. The duration of locomotor activity following lights-on under 12 hour light:12 hour dark ( 12:12LD ) conditions is significantly longer in Clkper.T:Ivir\HA1 flies compared to control flies. The timing of the evening peak of activity starts about 30 minutes earlier than in control flies and Clkper.T:Ivir\HA1 flies show a significantly higher portion of their daily locomotor activity during the light phase. Brief light pulses given during the first day of constant darkness conditions elicit high levels of activity in both Clkper.T:Ivir\HA1 and control flies, but the bouts of activity last longer in Clkper.T:Ivir\HA1 flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Clkper.T:Ivir\HA1
Clkper.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (3)