FB2024_03 , released June 25, 2024
Allele: Dmel\E2f2k16402a
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General Information
Symbol
Dmel\E2f2k16402a
Species
D. melanogaster
Name
FlyBase ID
FBal0134270
Feature type
allele
Associated gene
Dmel\E2f2
Associated Insertion(s)
P{lacW}Mpp6k16402a
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cayirlioglu et al., 2001)
Mutagen
P-element activity
(Cayirlioglu et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{lacW}Mpp6k16402a
Cytology
Description

P{lacW} insertion 856bp upstream of the E2f2 translation start site (insertion is approximately 650bp upstream of the transcription start site).

(Cayirlioglu et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      44% of eggs laid by E2f2k16402a/Df(2L)DS8 females carrying E2f21-188 (with Mpp6 function rescued by Mpp6+t1-188) hatch. 84% of the eggs laid by these females have chorion defects. 88% of the egg chambers of these females have an abnormal BrdU incorporation pattern in the follicle cell nuclei. Three types of abnormal incorporation pattern are seen; incorporation throughout the nucleus, lack of incorporation and nuclei containing both gene amplification foci and genomic incorporation.

      (Cayirlioglu et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: P{lacW}k16402b. Separable from: P{lacW}k16402c. Associated with: Mpp6k16402a. The lethality caused by the P{lacW}Mpp6k16402a insertion is associated with Mpp6k16402a and not with E2f2k16402a.

      (Cayirlioglu et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      E2f216402a
      (Cayirlioglu et al., 2001)
      E2f2k16402a
      Name Synonyms
      Secondary FlyBase IDs
        References (1)