FB2024_03 , released June 25, 2024
Allele: Dmel\AntpK50.UAS
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General Information
Symbol
Dmel\AntpK50.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0123320
Feature type
allele
Associated gene
Dmel\Antp
Associated Insertion(s)
Carried in Construct
P{UAS-Antp.Q50K.C}
Also Known As
UAS-AntpK50
Key Links
Transgenic product class
missense_variant
(Capovilla et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Capovilla et al., 2001)
Mutagen
in vitro construct
(Capovilla et al., 2001, Plaza et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-Antp.Q50K.C}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Antp that contains a Gln to Lys mutation at the 50th codon of the homeodomain.

(Capovilla et al., 2001)

UASt sequences drive expression of a mutated Antp. The DNA-binding specificity has been changed to that of bcd.

(Plaza et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Antp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AntpK50.Scer\UAS under the control of Scer\GAL4dpp.blk1 does not result in antenna-to-leg transformation or reduction of the eye.

      Expression of AntpK50.Scer\UAS under the control of Scer\GAL4ey-OK107 results in less than 10% pupal lethality. 25-50% of animals show a reduction in the eye compared to wild type.

      (Plaza et al., 2008)

      Expression of AntpK50.Scer\UAS under the control of Scer\GAL4sca-537.4 results in a wildtype-like embryonic brain.

      (Sprecher et al., 2004)

      When expression is driven by Scer\GAL4how-24B and Scer\GAL4twi.PG some of the lateral transverse muscles present abnormal shape and orientation.

      (Capovilla et al., 2001)

      AntpK50.Scer\UAS when driven by Scer\GAL4ey.PH represses eye development.

      (Plaza et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Misexpression of Nact.sev with AntpK50.Scer\UAS under the control of Scer\GAL4ey.PH results in an arista-to-tarsus transformation phenotype. These mutants exhibit some antenna-to-leg transformation but fail to induce ectopic wing tissue in the eye.

      (Prince et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AntpK50.Scer\UAS
      AntpK50.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)