FB2024_03 , released June 25, 2024
Allele: Dmel\fraΔC.UAS.Tag:MYC
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General Information
Symbol
Dmel\fraΔC.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0118236
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of fra lacking the cytoplasmic domain, and tagged with Tag:MYC.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of fraΔC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4605 in fra3/fra4 embryos results in abnormal spreading of the dMP2 growth cone over the region of induced ectopic NetB accumulation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

fra3 strongly suppresses the dMP2 axon misprojection phenotype seen in homozygous robo1 embryos, reducing the penetrance of the contralateral misprojection along the anterior commissure of the next segment from 99% to 24%. Expression of fraΔC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4insc-Mz1407, but not under the control of Scer\GAL415J2, restores the aberrant midline-crossing phenotype in these animals.

The pCC and vMP2 midline-crossing phenotypes seen in homozygous robo1 embryos are partially and strongly suppressed by fra3 respectively. Expression of fraΔC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4605 restores the aberrant midline-crossing phenotype in these animals.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
fraΔC.Scer\UAS.T:Hsap\MYC
fraΔC.UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (2)