Mutation in the proximal E2f protein binding sites of the Orc1 promoter.
Encodes an unstable protein, the half-life of which is short with respect to the length of the cell cycle. Accumulation of the protein therefore monitors newly synthesised protein, allowing examination of cell cycle-regulated transcription in vivo.
Encodes an unstable protein, the half-life of which is short with respect to the length of the cell cycle. Accumulation of the protein therefore monitors newly synthesised protein, allowing examination of cell cycle-regulated transcription in vivo.