Ectodermal cells of embryos ectopically expressing inscNLS.hs.T:Zzzz\FLAG do not show reorientation of their mitotic spindles. Embryos expressing inscNLS.hs.T:Zzzz\FLAG show gross morphological defects late in development, including a high frequency of RP2 neuron loss, occasional reduction or loss of EL clusters, a general spatial disorder of the central nervous system, and defects in gut development.