FB2024_03 , released June 25, 2024
Allele: Dmel\slo18
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General Information
Symbol
Dmel\slo18
Species
D. melanogaster
Name
FlyBase ID
FBal0095196
Feature type
allele
Associated gene
Dmel\slo
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(3R)ash18
    Cytology
    Description

    Deficiency breakpoint between the C1 promoter and C2 promoter of slo, removing the C0 and C1 promoters.

    (Atkinson et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        slo18/slo4 transheterozygotes are unable to acquire benzyl alcohol resistance, while slo4/+ heterozygotes acquire resistance normally.

        (Ghezzi et al., 2004)

        slo18/slo4 flies show a 'sticky-feet' phenotype; their feet appear to be stuck to the ground. These flies fly well.

        (Srinivasan et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Complements

        slo1

        (Atkinson et al., 2000)
        Partially complements

        slo4

        (Atkinson et al., 2000)
        Comments

        slo18 completely complements the slo4 action potential phenotype; slo4/slo18 indirect flight muscles have action potentials of normal shape and duration. The flight behaviour defective phenotype of slo4 or slo1 is also complemented by slo18. slo18 fails to complement the slo4 "sticky-feet" phenotype seen after exposure to bright light.

        (Atkinson et al., 2000)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        slo18
        Name Synonyms
        Secondary FlyBase IDs
          References (3)