FB2024_03 , released June 25, 2024
Allele: Dmel\fzUAS.N
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General Information
Symbol
Dmel\fzUAS.N
Species
D. melanogaster
Name
FlyBase ID
FBal0092979
Feature type
allele
Associated gene
Dmel\fz
Associated Insertion(s)
Carried in Construct
P{UAS-fz.N}
Also Known As
UAS-fzDN
Key Links
Transgenic product class
inframe_deletion
(Zhang and Carthew, 1998)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zhang and Carthew, 1998)
Mutagen
in vitro construct
(Zhang and Carthew, 1998)
Progenitor genotype
Carried in construct
P{UAS-fz.N}
Cytology
Description

cDNA sequence nucleotides 589-1413 (FBrf0050626) is expressed from UASt regulatory sequences. This includes coding sequence for the N-terminal 272 amino acids which encompasses the first transmembrane domain and the first two residues of the first intracellular loop, and was put in frame with a heterologous RWL peptide followed by a stop codon. Contains 9 nucleotides of 5' UTR.

(Zhang and Carthew, 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing fzUAS.N under the control of Scer\GAL4HCH.Hand fails to induce defects in heart morphology or ostia formation in embryos.

      (Chen et al., 2016)

      Expression of fzScer\UAS.N under the control of Scer\GAL4dome-PG14 results in mislocalisation of hemocyte precursors from the medullary zone into the cortical zone of the lymph gland, and differentiation of hemocyte precursors into plasmatocytes is observed.

      Expression of fzScer\UAS.N under the control of Scer\GAL4Antp-10 does not cause a reduction in the number of cells of the posterior signalling center of the lymph gland.

      Expression of fzScer\UAS.N under the control of Scer\GAL4lz-gal4 does not affect the number of crystal cells.

      (Sinenko et al., 2009)

      Expression of fzScer\UAS.N under the control of Scer\GAL4fkh.PZ results in salivary gland guidance defects; a large portion of the salivary gland curves towards the central nervous system, with the curving beginning early, as the gland migrates along the circular visceral mesoderm.

      (Harris and Beckendorf, 2007)

      Expression of fzScer\UAS.N under the control of Scer\GAL4dpp.blk1 has no effect on furrow formation in the eye disc.

      (Kumar and Moses, 2001)

      Expression of fzScer\UAS.N under the control of Scer\GAL4da.G32 results in a phenotype similar to that produced by overexpression of sgg.

      (Buratovich et al., 2000)

      No RP2/sib lineage defect is seen in embryos expressing fzScer\UAS.N under the control of Scer\GAL4da.G32.

      (Bhat, 1998)

      When expression is driven by Scer\GAL4hs.2sev, the two chiral forms of ommatidia are intermixed in the dorsal and ventral half of the eye. When expression is driven by Scer\GAL469B, posterior wing margin and anterior bristles are partially lost. This can be rescued by co-expression with fzScer\UAS.cZa.

      (Zhang and Carthew, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL469B, fzUAS.N has visible phenotype, enhanceable by dsh3

      (Zhang and Carthew, 1998)

      Scer\GAL469B, fzUAS.N has visible phenotype, enhanceable by arm1

      (Zhang and Carthew, 1998)
      Suppressed by
      Statement
      Reference

      Scer\GAL469B, fzUAS.N has visible phenotype, suppressible by wgl-17

      (Zhang and Carthew, 1998)

      Scer\GAL469B, fzUAS.N has visible phenotype, suppressible by sggM11

      (Zhang and Carthew, 1998)

      Scer\GAL469B, fzUAS.N has visible phenotype, suppressible by fz2UAS.cZa/Scer\GAL469B

      (Zhang and Carthew, 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of fzScer\UAS.N and fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dome-PG14 results in mislocalisation of hemocyte precursors from the medullary zone into the cortical zone of the lymph gland, and differentiation of hemocyte precursors into plasmatocytes is observed.

      (Sinenko et al., 2009)

      The phenotype caused by expression of fzScer\UAS.N using Scer\GAL469B can be rescued by co-expression with fz2Scer\UAS.cZa. This phenotype can be dominantly suppressed by wgl-17. When expression is driven by Scer\GAL469B, ectopic wing bristle phenotype of fz2Scer\UAS.cZa is suppressed.

      (Zhang and Carthew, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      fzUAS.N is rescued by fzUAS.cZa/Scer\GAL469B

      (Zhang and Carthew, 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fzScer\UAS.N
      fzUAS.N
      Name Synonyms
      Secondary FlyBase IDs
        References (7)