FB2024_03 , released June 25, 2024
Allele: Dmel\bossExboss-GCNa.hs
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General Information
Symbol
Dmel\bossExboss-GCNa.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0089437
Feature type
allele
Associated gene
Dmel\boss
Associated Insertion(s)
Carried in Construct
P{HS-Exboss-GCNa}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Sevrioukov et al., 1998)
Progenitor genotype
Carried in construct
P{HS-Exboss-GCNa}
Cytology
Description

A heat inducible promoter drives expression of sequence encoding the secreted extracellular domain of boss fused to a leucine zipper derived from the Saccharomyces cerevisiae GCN4 gene (GCN4 sequence starts at residue 249, which directly precedes the leucine zipper). The presence of the leucine zipper results in the protein produced forming dimers.

(Sevrioukov et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
boss
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heat induced expression during larval development of boss1 mutants produces adults that exhibit dorsal-ventral stripes of ommatidia lacking R7 cells.

      (Sevrioukov et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "Exboss-GCNa", expressed in S2 cells and oligomerisation of the fusion protein is studied.

      (Sevrioukov et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      boss::Scer\GCN4a.hs
      bossExboss-GCNa.hs
      bossa.hs.T:Scer\GCN4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)