FB2024_03 , released June 25, 2024
Allele: Dmel\tocotu.PG
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General Information
Symbol
Dmel\tocotu.PG
Species
D. melanogaster
Name
ovarian tumor promoter construct of Grammont
FlyBase ID
FBal0086287
Feature type
allele
Associated gene
Dmel\toc
Associated Insertion(s)
Carried in Construct
P{otu-toc.G}
Key Links
Transgenic product class
cDNA
(Grammont et al., 1997)
wild_type
(Grammont et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Grammont et al., 1997)
wild_type
(Grammont et al., 1997)
Mutagen
in vitro construct
(Grammont et al., 1997)
Progenitor genotype
Carried in construct
P{otu-toc.G}
Cytology
Description

otu promoter drives expression of toc cDNA.

(Grammont et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
otu
Encoded product / tool
toc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectopic expression of toc in germ line cells leads to the formation of normal egg chambers containing a single 16-cell cyst. A large proportion of eggs laid develop into wild type embryos. The egg chambers are separated from each other by stalks of 10-15 cells, compared to 4-6 in wild type ovaries. The extra interfollicular cells are either correctly organised into a stalk or form a cluster around one of the central interfollicular cells.

      (Grammont et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tocotu.PG
      Name Synonyms
      ovarian tumor promoter construct of Grammont
      (Grammont et al., 1997)
      Secondary FlyBase IDs
        References (1)